生物医学分析化学教育部重点实验室欢迎您
 
教师入口 用户名:  码: 设为首页 加入收藏 English
生物医学分析化学教育部重点实验室
首 页 实验室简介 实验室组织 研究队伍 研究方向 研究项目 成果奖励 仪器设备 运行与管理 人才培养 开放与交流
 
   
   
   
   
   
   
 
   
 
  通知公告  
 
    凌代舜教授学术报告信息(2016年6月13号下午3:00,化西210)

发布时间: 2016-6-12

报告题目:Surface Ligand in Modification and Assembly ofMultifunctional Nanoparticles for Biomedical Applications

报告人:凌代舜教授(浙江大学,国家青年千人计划入选者)

时间:2016年6月13号下午3:00

地点:化西210会议室

 

摘要:Nanotechnology has received extraordinary attention recently due to its burgeoning role in pharmaceutical research. The materials composing the nanoparticles produce fascinating and diversefunctionalities as a result of their exceptionally small size. Size control, both during synthesis andin particle suspensions, is a sine qua non for functionality. This can be accomplished by maskingthe particle surface with a multitude of different ligands [1, 2]. Ligands are essentially fungibleand can be exchanged at various times to confer the desired properties to the particle. This caninclude protecting the particle from harsh aqueous conditions [3, 4], such as pH extremes,maximizing optical properties for diagnostics or shielding the particle from potentially hostileconditions found in the body. The design of the ligand can have crucial effects on biodistributionas well as evasion of biological defenses. Ligands can even be designed to provide newfunctionality in response to various environmental stimuli to improve their therapeutic ordiagnostic capabilities [5, 6]. Clever combination of different nanoscale materials via ligand directed self-assembly will lead to the development of multifunctional nano-biomedical platformsfor advanced drug delivery system such as simultaneous targeted delivery, fast diagnosis, and efficient therapy [7-11].

 

[1] D. Ling et al. Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles Nano Today, 9:457–477, 2014.

[2] D. Ling et al. Chemical design of biocompatible iron oxide nanoparticles for medical applications. Small, 9:1450-1466, 2013.

[3] D. Ling et al. Multiple‐Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles. Angew. Chem.Int. Ed., 50, 11360–11365, 2011.

[4] D. Ling et al.A General Strategy for Site‐Directed Enzyme Immobilization by Using NiO Nanoparticle Decorated Mesoporous Silica. Chem. Eur. J., 20:7916 – 7921,2014.

[5] D. Ling et al. Cancer imaging: Lighting up tumours. Nature Mater.,13, 122-124,2014.

[6] D. Ling et al. pH-Sensitive NanoformulatedTriptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma. ACS Nano, 8:8027–8039, 2014.

[7] D. Ling et al. Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors. J. Am. Chem. Soc., 2014, 136, 5647–5655

[8] Michael A. Boles, Daishun Linget al.  The surface science of nanocrystals, Nature Materials, in press

[9] D. Ling et al. Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nano-carrier-mediated nuclear targeting. Biomaterials, 21:5478-5486, 2012.

[10] D. Ling et al. Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications. Acc. Chem. Res., 48:1276–1285, 2015.

[11] Rui Chen, Daishun Ling*et al, Parallel Comparative Studies on Mouse Toxicity of Oxide Nanoparticle- and Gadolinium-Based T1 MRI Contrast Agents, ACS Nano, 2015, 9, 12425-12435.

 
 

 

 
无标题文档
 
地址:武汉市武昌区珞珈山(430072) 电话:027-68756759 电子邮箱:anal@whu.edu.cn
Copyright©2009 analchem.whu.edu.cn 生物医学分析化学教育部重点实验室