袁必锋

姓名:袁必锋

职务职称:教授、博导

专业:分析化学

最终学位:博士

研究方向:生物分析化学(Bioanalytical chemistry)/ 色谱-质谱分析

工作分工:


中文简历:教育与研究经历

1997. 9 - 2001. 6 武汉大学 生命科学学院 生物化学专业 学士

2001. 9 - 2006. 6 武汉大学 生命科学学院 生物物理专业 博士

2006. 11 - 2007. 6 新加坡国立大学 生物科学系 博士后

2007. 7 - 2011. 1 美国加州大学河滨分校 化学系 博士后

2011. 2 至今 武汉大学 化学与分子科学学院 教授/博导


研究领域与兴趣

1. 核酸表观遗传修饰(Epigenetic Modifications)

核酸表观遗传修饰不仅在基因调控等方面有重要作用,而且在癌症等许多疾病的发生中也扮演着重要角色。本课题组通过建立质谱分析等研究方法,对核酸表观遗传修饰的生理功能进行研究。

2. 代谢组学(Metabolomics)

发展基于质谱技术的代谢组学研究方法,结合相应的生物学手段,探索代谢物在疾病发生、发展过程中的生理功能。

发表论文: 1. Yuan, B.F.* and Feng, Y.Q. (2014) Recent advances in the analysis of 5-methylcytosine and its oxidation products. TrAC-Trend Anal. Chem., 54, 24-35.

2. Wang, S.T., Huang, W., Lu, W., Yuan, B.F.* and Feng, Y.Q.* (2013) TiO2-Based Solid Phase Extraction Strategy for Highly Effective Elimination of Normal Ribonucleosides before Detection of 2'-Deoxynucleosides/Low-Abundance 2'-O-Modified Ribonucleosides. Anal Chem, 85, 10512-10518.

3. Tang, Y., Chu, J.M., Huang, W., Xiong, J., Xing, X.W., Zhou, X., Feng, Y.Q.* and Yuan, B.F.* (2013) Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography-tandem mass spectrometry detection. Anal Chem, 85, 6129-6135.

4. Chen, M.L., Shen, F., Huang, W., Qi, J.H., Wang, Y., Feng, Y.Q.*, Liu, S.M.* and Yuan, B.F.* (2013) Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine in Genomic DNA from Hepatocellular Carcinoma Tissues by Capillary Hydrophilic-Interaction Liquid Chromatography/Quadrupole TOF Mass Spectrometry. Clin Chem, 59, 824-832.

5. Chen, M.L., Liu, Y.L., Xing, X.W., Zhou, X., Feng, Y.Q.* and Yuan, B.F.* (2013) Preparation of a Hyper-cross-linked Polymer Monolithic Column and Its Application to the Sensitive Determination of Genomic DNA Methylation. Chemistry, 19, 1035-1041.

6. Tang, Y., Gao, X.D., Wang, Y., Yuan, B.F.* and Feng, Y.Q.* (2012) Widespread existence of Cytosine methylation in yeast DNA measured by gas chromatography/mass spectrometry. Anal Chem, 84, 7249-7255.

7. Yuan, B.F., Wang, J., Cao, H., Sun, R. and Wang, Y.* (2011) High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing. Nucleic Acids Res, 39, 5945-5954.

8. Yuan, B.F., Zhang, J., Wang, H., Xiong, L., Cai, Q., Wang, T., Jacobsen, S., Pradhan, S. and Wang, Y.* (2011) 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res, 71, 1904-1911.

9. Yuan, B.F., O'Connor, T.R. and Wang, Y.* (2010) 6-Thioguanine and S(6)-Methylthioguanine Are Mutagenic in Human Cells. ACS Chem. Biol., 5, 1021-1027.

10. Yuan, B.F., Cao, H., Jiang, Y., Hong, H. and Wang, Y.* (2008) Efficient and accurate bypass of N2-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo. Proc. Natl. Acad. Sci. U S A., 105, 8679-8684.



发表的全部论文可以从下面的NCBI连接查看(Full pubulications link)

http://www.ncbi.nlm.nih.gov/pubmed?term=bifeng%20yuan%20or%20bi%20feng%20yuan

实验室主页:
http://www.chem.whu.edu.cn/Teacher/162025577.htm

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